Severe Systemic Reaction to Topical Imiquimod
نویسندگان
چکیده
منابع مشابه
Topical imiquimod yields systemic effects due to unintended oral uptake
Repetitive application of topical imiquimod is used as an experimental model for the induction of psoriasiform skin lesions in mice. The model is characterized by several inflammatory processes, including cytokine production both locally and systemically, cellular infiltration, and splenomegaly. To investigate the production of type I interferons in response to imiquimod-containing Aldara cream...
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An 82-year-old man with severe cardiac arrhythmia and recurrent heart failure presented with a 3-year history of erythematous plaques on the left orbita and on the chest. The lesion on his left eye was a hypertrophic actinic keratosis (231.5 cm), a scaly erythematous plaque on the saddle of the nose extending to the opening of the left lacrimal duct. The chest lesion consisted of a 532.5-cm pla...
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Lentigo maligna (LM) is the in situ phase of lentigo maligna melanoma, which may progress to invasive melanoma if left untreated. It mainly occurs on sun-exposed areas of elderly patients. The lesions can be large and conventional surgery can be difficult, particularly on the face. Recent reports indicate that topical imiquimod 5% cream is effective in the treatment of LM. It may be an alternat...
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An 86-year-old woman presented in 1999 with a malignant melanoma (Clark level IV; Breslow thickness, 1.9 mm) on her right knee, which was initially treated with wide excision. In August 2000, several skin lesions of metastatic melanoma were noted on the right lower leg. These were treated with carbon-dioxide laser ablation. Multiple new skin-colored, brownish red, and dark blue smooth-surfaced ...
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A published case report and anecdotal experience suggested that topical imiquimod is an effective treatment for stage 0 melanoma (lentigo maligna). To gauge the efficacy of this therapy, we undertook a trial of topical imiquimod in 30 subjects with histologically confirmed lentigo maligna. Thirty subjects with lentigo maligna were recruited for an open-labelled efficacy trial with daily topical...
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ژورنال
عنوان ژورنال: Acta Dermato Venereologica
سال: 2011
ISSN: 0001-5555
DOI: 10.2340/00015555-1121